In attempting to reopen a doorway into the TARDIS, Turlough activates Terminus' automated fuel-jettisoning sequence. The first time this sequence was engaged, it flung its first of two massive loads of unstable fuel into the distant past, producing the Big Bang that created the universe. This second sequence - if the Doctor can't find a way to shut it down - will release a second massive load, the explosion of which will entirely negate the effects of the first. (thetvdb.com)